Probabilistic Bounds on the Length of a Longest Edge in Delaunay Graphs of Random Points in d-Dimensions

Motivated by low energy consumption in geographic routing in wireless networks, there has been recent interest in determining bounds on the length of edges in the Delaunay graph of randomly distributed points. Asymptotic results are known for random networks in planar domains. In this paper, we obtain upper and lower bounds that hold with parametric probability in any dimension, for points distributed uniformly at random in domains with and without boundary. The results obtained are asymptotically tight for all relevant values of such probability and constant number of dimensions, and show that the overhead produced by boundary nodes in the plane holds also for higher dimensions. To our knowledge, this is the first comprehensive study on the lengths of long edges in Delaunay graphsComment: 10 pages. 2 figures. In Proceedings of the 23rd Canadian Conference on Computational Geometry (CCCG 2011). Replacement of version 1106.4927, reference [5] adde

Sur8, a determinant protein in colorectal cancer tumor progression

Resumen del trabajo presentado en el 43rd Annual Meeting of the SEBBM, celebrado en Barcelona (España) del 19 al 21 de julio de 2021.Colorectal cancer (CRC) has the highest incidence rate in the Spanish population. The most important challenge consists on the discovery of efficient disease treatments, due to high mortality rates in highly developed stages. Sur8 is a scaffold protein that positively modulates ERK signaling pathway, which has a major role in the progression and metastasis in colorectal cancer. The main goals of our research are to determine the role that Sur8 plays in the development and progression of CRC and to analyze its possible therapeutic potential. For this purpose, our group has developed an inducible conditional mouse model msur8f/fVillinCreERT2. In order to determine Sur8 action in the colonic tissue, we have developed organoids from the colon epithelium of healthy mice and have analyzed gene expression pattern by an RNAseq approach. Sur8 KO affects oncogenic CRC transcription factors expression, as well as the modulation of some Wnt pathway regulators. In regard to miRNA data, we have observed deregulation of miRNAs related to CRC in Sur8 KO organoids. To determine the role that Sur8 plays in the development and progression of CRC, we have subjected our inducible conditional mice to chemical carcinogenesis and we have observed that Sur8 KO males display less and smaller tumors and do not present any adenocarcinoma. In addition, we have carried out Sur8 silencing in human CRC cell lines by infection with constitutive shRNA lentiviruses. We have observed that Sur8 silencing produces decreases of cell tumor proliferation, and reduction of p-ERK levels. Finally, we are evaluating the effects of putative therapeutic agents against Sur8 in human CRC cell lines. Concretely, we are testing Celastrol, which has been described that binds and blocks the action of Sur8 in vitro. We have observed that Celastrol treatment diminishes the cell tumor proliferation in this model. Altogether, our results indicate that Sur8 may have a determinant role in CRC progression and that Sur8 could be a potential molecular target for the design of novel strategies against CRC

The impact of mobility on the geocasting problem in mobile ad-hoc networks: Solvability and cost

We present a model of a mobile ad-hoc network in which nodes can move arbitrarily on the plane with some bounded speed. We show that without any assumption on some topological stability, it is impossible to solve the geocast problem deterministically despite connectivity and no matter how slowly the nodes move. Moreover, even if each node maintains a stable connection with each of its neighbors for some period of time, it is impossible to solve the geocast problem if nodes move too fast. Additionally, we give a tradeoff lower bound which shows that the faster the nodes can move on a monodimensional space, the more costly it would be to solve the geocast problem. We provide geocasting algorithms for the case where nodes move in one dimension and also when they can move on the plane (i.e., in two dimensions). We prove correctness of our algorithms by giving exact bounds on the speed of movement. Our analysis helps understand the impact of speed of nodes, firstly, on geocasting solvability and, secondly, on the cost of geocasting. © 2010 Elsevier B.V. All rights reserved

Unbounded contention resolution in multiple-access channels

The Western philosophy postulates present reason and emotion as antagonistic forces that motivate individuals in their everyday decision making. In the Western culture, reason has had to dominate emotion so as to reach objective decisions. Habermas hypothesis about the rational dimension of the public sphere reaffirms this tendency that states the public domain should find an order based on rational principles. Although rationalism is still predominant among Social Science researchers, a change in the approaches is evident: emotions have begun to be included in studies when the comprehension of contemporary phenomenon is necessary. Particularly, in the political communication field, emotion as a topic of exploration is new. However, new disciplinary perspectives allow innovating in research inquiries. The aim of this article is to examine literature about the main postulates of the Affective Intelligence Theory which, with Neuroscience, offer other perspectives to the political communication field.Los postulados de la filosofía occidental presentan a la razón y la emoción como dos fuerzas antagónicas. En Occidente, la razón ha tenido que imponerse por sobre la emoción para que las personas tomaran sus decisiones objetivamente. El planteo de Habermas sobre la dimensión racional de la esfera pública reafirma esta tendencia, al considerar que el dominio de lo público debe buscar un orden basado en principios racionales. Si bien en las investigaciones en ciencias sociales el racionalismo continúa predominando, se evidencia un giro en los abordajes, que incorporan el ámbito emocional para comprender fenómenos contemporáneos. Particularmente en la comunicación política, la aproximación a las emociones como objeto de estudio es aún incipiente. Sin embargo, nuevas perspectivas disciplinares permiten innovar en las líneas de investigación en este campo. El objetivo de este artículo es realizar una revisión bibliográfica de los principales postulados de la teoría de la inteligencia afectiva que, de la mano de la neurociencia, aportan otras miradas a los procesos de comunicación política.